E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat [Tr-ENT]
Tr-ENT. 2018; 28(2): 66-70 | DOI: 10.5606/Tr-ENT.2018.04453

Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Kazım Bozdemir1, Arife Sezgin2, Ahmet Akkoz1, Özcan Erel3, Mehmet Hakan Korkmaz1
1Department of Otolaryngology, Medicine Faculty of Yıldırım Beyazıt University, Ankara, Turkey
2Department of Otolaryngology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
3Department of Biochemistry, Medicine Faculty of Yıldırım Beyazıt University, Ankara, Turkey

INTRODUCTION: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis.
METHODS: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.
RESULTS: The average native thiol value of the chronic sinusitis group was 475.6 μmol/L and 515.8 μmol/L in the control group. The total thiol was 509.4 and 552.2 μmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients had significantly lower native and thiol value than control group (p<.001 and p=.001). There was no significant difference between chronic sinusitis and control groups with respect to disulphide levels.
DISCUSSION AND CONCLUSION: Serum thiol and disulphide measurements can be used as a novel method for the reflection of inflammation for chronic rhinosinusitis patients.

Keywords: Chronic sinusitis, homesostasis, thiol-disulphide.

Kazım Bozdemir, Arife Sezgin, Ahmet Akkoz, Özcan Erel, Mehmet Hakan Korkmaz. Thiol-disulphide homeostasis in chronic sinusitis without polyposis. Tr-ENT. 2018; 28(2): 66-70

Sorumlu Yazar: Arife Sezgin, Türkiye
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