INTRODUCTION: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis.
METHODS: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.
RESULTS: The average native thiol value of the chronic sinusitis group was 475.6 μmol/L and 515.8 μmol/L in the control group. The total thiol was 509.4 and 552.2 μmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients had significantly lower native and thiol value than control group (p<.001 and p=.001). There was no significant difference between chronic sinusitis and control groups with respect to disulphide levels.
DISCUSSION AND CONCLUSION: Serum thiol and disulphide measurements can be used as a novel method for the reflection of inflammation for chronic rhinosinusitis patients.