INTRODUCTION: This study aims to investigate the protective effect of hyperbaric oxygen therapy (HBOT) as an antioxidant agent on cisplatin ototoxicity.
METHODS: Between June 4th, 2014 and June 13th, 2014, a total of 15 adult female Wistar albino rats were used in this study. The rats were divided into the following groups: Group A comprised of five rats and had prophylactic one course of HBOT before intraperitoneal (IP) cisplatin injection, followed by two more courses of HBOT. Group B comprised of five rats receiving three cycles of HBOT after 10 mg/kg of IP cisplatin administration. Group C served as the control group, including five rats, and received 10 mg/kg IP cisplatin without any additional treatment. The distortion product otoacoustic emission amplitudes of the rats were obtained before and after the study.
RESULTS: Group A and Group C showed a significant decrease in all measurements (4,004 Hz, 4,761 Hz, 5,188 Hz, 5,652 Hz, 6,726 Hz, and 7,996 Hz) after cisplatin administration compared to that of baseline measurement. In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz.
DISCUSSION AND CONCLUSION: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.