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Efficacy of topical ciprofloxacin and tobramycin in combination with dexamethasone in the treatment of chronic suppurative otitis media [Tr-ENT]
Tr-ENT. 2002; 9(2): 106-111

Efficacy of topical ciprofloxacin and tobramycin in combination with dexamethasone in the treatment of chronic suppurative otitis media

İrfan Kaygusuz1, Turgut Karlıdağ, Üzeyir Gök, Şinasi Yalçın, Erol Keleş, Erhan Demirbağ, Türkkan Öztürk Kaygusuz

Objectives: To evaluate the efficacy of topical
ciprofloxacin and tobramycin with and without topical
dexamethasone in the treatment of chronic suppurative
otitis media without cholesteatoma.
Patients and Methods: The study included 103 ears of
80 patients (49 males, 31 females; mean age 31 years;
range 18 to 60 years) with chronic suppurative otitis
media without cholesteatoma. The patients were randomly
divided into four groups to receive topical applications
of either ciprofloxacin and tobramycin alone, or in combination
with dexamethasone. Cultures were obtained from
the ears preoperatively and 24 hours after treatment.
Results: Aerobic bacteria were isolated in 94.1% of patients
before the treatment, the most common being
Pseudomonas aeruginosa (38.9%). With dexamethasone,
the clinical response for ciprofloxacin and tobramycin
increased from 80% to 90% and from 70% to 75%, respectively,
but this improvement was not significant (p>0.03).
Addition of dexamethasone to ciprofloxacin decreased the
recovery period from 14 days to seven days, whereas no
change (7 days) was observed with tobramycin.
Conclusion: The efficacy of ciprofloxacin and
tobramycin were similar in the treatment of chronic suppurative
otitis media. Addition of dexamethasone to
ciprofloxacin decreased the treatment period.

Keywords: Administration, topical; ciprofloxacin/therapeutic use;dexamethasone/therapeutic use; glucocorticoids, topical; otitismedia, suppurative/microbiology/drug therapy; Pseudomonasaeruginosa; tobramycin/therapeutic use.

Kronik süpüratif otitis media tedavisinde topikal siprofloksasin ve tobramisinin deksametazon ile kullanımı*

İrfan Kaygusuz1, Turgut Karlıdağ, Üzeyir Gök, Şinasi Yalçın, Erol Keleş, Erhan Demirbağ, Türkkan Öztürk Kaygusuz

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Anahtar Kelimeler: Uygulama, topikal; siprofloksasin/terapötikkullanım; deksametason/terapötik kullanım; glukokortikoid, topikal;otitis media, süpüratif/mikrobiyoloji/ilaç tedavisi; Pseudomonasaeruginosa; tobramisin//terapötik kullanım.

İrfan Kaygusuz, Turgut Karlıdağ, Üzeyir Gök, Şinasi Yalçın, Erol Keleş, Erhan Demirbağ, Türkkan Öztürk Kaygusuz. Efficacy of topical ciprofloxacin and tobramycin in combination with dexamethasone in the treatment of chronic suppurative otitis media. Tr-ENT. 2002; 9(2): 106-111

Corresponding Author: İrfan Kaygusuz
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