Objectives: The efficacy and reliability of prophylactic antiemetic
therapy with low dose propofol, droperidol, metoclopramide
and ondansetron were evaluated in a randomized, doubleblind,
and prospective design.
Patients and Methods: A total of 101 ASA I-II patients (34
females, 67 males; age range 16 to 53 years) undergoing
middle ear surgery for chronic otitis media or its sequelae
were randomly assigned to receive prophylactic antiemetic
therapy with propofol (n=21, 0.5 mg/kg), droperidol (n=19, 20
mg/kg), metoclopramide (n=23, 0.2 mg/kg), ondansetron
(n=21, 4 mg), and placebo (n=20, 0.9% NaCl). All drugs were
administered intravenously five minutes before extubation.
Resul t s: In the early postoperative period (0 to 3 hours), the
percentages of patients free from nausea and vomiting were
100% with droperidol, 71.4% with ondansetron and propofol,
52.1% with metoclopramide, and 35% with placebo.
Ondansetron (90.4%) was found the most effective to prevent
and control nausea and vomiting during the postoperative
3 to 24 hours, followed by droperidol (84.2%), propofol
(57.1%), metoclopramide (47.8%), and placebo (40%).
Compared with controls, the number of patients without nausea
and vomiting was significantly greater in each treatment
group but metoclopramide (p<0.05). No significant differences
were detected with respect to adverse effects.
Conclusion: Droperidol and ondansetron seem to exert the
highest efficacy to prevent nausea and vomiting during the
postoperative 0 to 3 hours and 3 to 24 hours, respectively.
FREE FULL TEXTAnahtar Kelimeler: Anestezi, genel; antiemetik/terapötik kullan ı m;droperidol/terapötik kullanım; kulak, orta/cerrahi; metoklopramid/ terapötikkullanım; ondansetron/terapötik kullanım; ameliyat sonrasıbulantı ve kusma/önleme ve kontrol; propofol/terapötik kullanım.