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The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy? [Tr-ENT]
Tr-ENT. 2003; 11(3): 80-84

The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy?

Levent Saydam1, M. Tayyar Kalcıoğlu, Ahmet Kızılay, Mete Kaan Bozkurt

Objectives: We evaluated the role of fine-needle
aspiration biopsy as a single parameter in determining
the extent of thyroidectomy and the necessity of
routine use of frozen-section examination in patients
with nodular thyroid disease.
Pat i ents and Methods: We reviewed 67 patients (40
females, 27 males; mean age 44 years; range 17 to 78
years) who underwent thyroidectomy for nodular thyroid
disease. Preoperative fine-needle aspiration biopsy and
intraoperative frozen-section examination were performed
in 46 patients and 40 patients, respectively. The
results were compared with histopathologic diagnoses.
Results: Histopathologically, 25 patients (37.3%)
had malignant and 42 patients (62.7%) had benign
disease. The sensitivity, specificity, and diagnostic
accuracy were 50%, 95%, and 77% for fine-needle
aspiration biopsy, and 100%, 87%, and 91% for
frozen-section examination, respectively.
Conclusion: In view of lower sensitivity and accuracy
rates for fine-needle aspiration biopsy, the routine use
of frozen-section examination seems to be necessary
especially in cases with highly suggestive clinical findings
of malignancy.

Keywords: Biopsy, needle; frozen sections; sensitivity andspecificity; thyroid diseases/diagnosis; thyroid gland/pathology/surgery; thyroid neoplasms/diagnosis; thyroid nodule/pathology/therapy; thyroidectomy.

Tiroit nodüllerinin değerlendirilmesi: İnce iğne aspirasyon biyopsisinden sonra frozen section incelemesi gerekli mi?

Levent Saydam1, M. Tayyar Kalcıoğlu, Ahmet Kızılay, Mete Kaan Bozkurt

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Anahtar Kelimeler: Biyopsi, iğne; frozen section; duyarlılıkve özgüllük; tiroit hastalıkları/tanı; tiroit bezi/patoloji/cerrahi;tiroit neoplazmları/tanı; tiroit nodülü/patoloji/tedavi; tiroidektomi

Levent Saydam, M. Tayyar Kalcıoğlu, Ahmet Kızılay, Mete Kaan Bozkurt. The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy?. Tr-ENT. 2003; 11(3): 80-84

Corresponding Author: Levent Saydam
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