E-ISSN 2602-4837
The efficacy of combined medical treatment (antihistaminics, steroids, and macrolide antibiotics) in patients with nasal polyposis: preliminary results [Tr-ENT]
Tr-ENT. 2002; 9(5): 352-357

The efficacy of combined medical treatment (antihistaminics, steroids, and macrolide antibiotics) in patients with nasal polyposis: preliminary results

Gökhan Kuran1, Sinan Kocatürk, Selma Kurukahvecioğlu, Ünsal Erkam

Objectives: We evaluated the efficacy of combined medical treatment in cases with bilateral nasal polyposis without a history of any surgical or medical treatment.
Patients and Methods: Twenty-five patients (19 males, 6 females; mean age 45 years; range 30 to 60 years) who had not received any treatment for bilateral nasal polyposis were included. Treatment was comprised of an oral anti-histaminic agent (single dose daily for 3 weeks), and a topical steroid (as a nasal spray, twice daily for 6 months) and a single dose of intramuscular systemic steroid. Patients who did not respond to this therapy at the end of three weeks were administered a macrolide antibiotic (clarithromycin). The results were evaluated before treatment, and three weeks and six months after treatment with the use of a patient questionnaire, computed tomography and endoscopic examination findings.
Results: The patients’ complaints improved by 85.5% and 79% at the end of three weeks and six months, respectively (p<0.005). Radiologic improvement was found to be 64% at the end of six months (p<0.005). The overall decrease in the size of the polyps was significant (p<0.005). No treatment-associated complications were encountered.
Conclusion: Significant improvement achieved favors the use of combined medical treatment before surgery in selected patients with nasal polyposis.

Keywords: Anti-inflammatory agents, steroidal/therapeutic use; antibiotics, macrolide/therapeutic use; clarithromycin/therapeutic use.

Nazal polipozisli hastalarda kombine antihistaminik, steroid ve makrolid tedavisinin etkinliği: Ön sonuçlar

Gökhan Kuran1, Sinan Kocatürk, Selma Kurukahvecioğlu, Ünsal Erkam

FREE FULL TEXT

Anahtar Kelimeler: Antienflamatuvar ajanlar, steroidal/terapötik kullanım; antibiyotik, makrolid/terapötik kullanım; klaritromisin/terapötik kullanım.

Gökhan Kuran, Sinan Kocatürk, Selma Kurukahvecioğlu, Ünsal Erkam. The efficacy of combined medical treatment (antihistaminics, steroids, and macrolide antibiotics) in patients with nasal polyposis: preliminary results. Tr-ENT. 2002; 9(5): 352-357

Corresponding Author: Gökhan Kuran
LookUs & Online Makale