Objectives: Reactive oxygen species (ROS) play
an important role in the pathogenesis of cancer. The
aim of this study was to investigate the extent of lipid
peroxidation and ROS in laryngeal cancer tissues.
Patients and Methods: We determined glutathione
(GSH) and malondialdehyde (MDA) activities as
markers of lipid peroxidation in laryngeal tumor specimens
and tumor-free adjacent tissues of 30 patients
with squamous cell carcinoma.
Results: Compared to the tumor-free specimens,
the level of GSH was significantly low (p<0.001)
whereas MDA, a lipid peroxidation product, showed
a significant increase (p<0.01) in cancer tissues. No
significant differences were found in MDA and GSH
levels between patients with early (n=14) and
advanced (n=16) tumor stages (p>0.05).
Conclusions: Decreased antioxidant capacity of
laryngeal cancer tissues results in elevation of
free oxygen radicals and increased lipid peroxidation.
Free radical metabolism may be involved in
the pathogenesis of laryngeal cancers.
FREE FULL TEXTAnahtar Kelimeler: Antioksidan/metabolizma; skuamözhücreli kanser; serbest radikal.