Objectives: The objective of the present study was
to determine the effect of zinc aspartate on myringosclerosis
in perforated rat tympanic membrane.
Patients and Methods: Fifteen Sprague-Dawley
rats were randomly divided into three groups each
containing five rats. Automicroscopic examinations
were performed and then all rats were bilaterally
myringotomized. Group 1 received no treatment.
Group 2 was treated with intraperitoneal injection of
physiological saline and group 3 with intraperitoneal
injection of zinc aspartate. Tympanic bullas were harvested
after 20 days. Histopathological evaluation
was carried out under the light microscope.
Results: When the groups were compared in the light of
the myringosclerotic findings, while there was no significant
difference between group 1 and 2 (p=1.00), it was
found that there were significant differences between
group 1 and 3, and between group 2 and 3 (p<0.03).
Conclusion: It appears that zinc aspartat treatment
has beneficial effects on prevention or retardation
of the development of myringosclerosis, but further
studies are needed to clarify this effect.
FREE FULL TEXTAnahtar Kelimeler: Miringoskleroz; sıçan timpanik membran;çinko aspartat.