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The Turkish Journal of Ear Nose and Throat Determination of allergen-specific IgE in patients with atopy or allergy symptoms [Tr-ENT]
Tr-ENT. 2003; 10(5): 188-193

Determination of allergen-specific IgE in patients with atopy or allergy symptoms

Murat Cem Miman1, İbrahim H. Özerol, Orhan Özturan, Tamer Erdem

Objectives: We investigated the role of specific IgE
assay in the diagnosis in patients found to be atopic
or allergic by history and physical examination.
Patients and Methods: Serum specific IgE levels
were measured by the chemiluminescent assay in
143 adults (58 females, 85 males; mean age 34.3
years; range 16 to 62 years) and in 113 children (62
girls, 51 boys; mean age 10.2 years; range 5 to 16
years) with rhinitis, asthma, or dermatitis. The
results were analyzed in six groups depending on
the specific IgE level (no specific IgE, very low, low,
moderate, high, and very high levels). The specific
IgE threshold for a negative or positive result was
accepted as 0.70 IU/ml. Allergen-specific IgE antibodies
were sought for 35 allergens in adults, and
for 19 allergens in children.
Results: Specific IgE levels were positive (>0.70
IU/ml) in 92 adults (64.34%) and in 50 children
(44.25%). Hypersensitivity to individual allergens
ranged between 20.08% and 41.96% in adults, and
between 17.70% and 28.32% in children. Fourteen
adults and eight children showed sensitivity to a single
allergen; the remaining patients were sensitive to
at least two allergens.
Conclusion: Detection of sensitivity to allergens is complementary
to findings obtained by history and physical
examination and may help to reveal allergic etiology in
patients presenting with a similar symptom profile.

Keywords: Allergens/immunology; hypersensitivity/ blood/diagnosis; immunoglobulin E/analysis/immunology.

Atopi veya alerjili olgularda alerjen-spesifik IgE düzeyleri

Murat Cem Miman1, İbrahim H. Özerol, Orhan Özturan, Tamer Erdem

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Anahtar Kelimeler: Alerjen/immünoloji; hipersensitivite/kan/tanı; immünglobulin E/analiz/immünoloji.

Murat Cem Miman, İbrahim H. Özerol, Orhan Özturan, Tamer Erdem. Determination of allergen-specific IgE in patients with atopy or allergy symptoms. Tr-ENT. 2003; 10(5): 188-193

Corresponding Author: Murat Cem Miman
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