Skin metastasis from laryngeal carcinoma is rare
and indicates a poor prognosis. A case of laryngeal
carcinoma with unusual metastasis to the skin of the
hand is reported. The patient had undergone total
laryngectomy, left radical neck dissection and right
functional neck dissection. After the operation, the
patient received radiotherapy. On the postoperative
18th month, a mass on the left hand was observed.
It was found to be a metastatic tumor from laryngeal
carcinoma, histopathologically as well as immunohistochemically.
Metastatic potential in malignant
neoplasm is generally correlated with reduced cellular
adhesiveness. We investigated the expression of
the vascular endothelial growth factor (VEGF),
matrix metalloproteinase-9 (MMP-9), E-cadherin.
Interestingly the immunohistochemical expression
characteristics of such an aggressive tumor are not
FREE FULL TEXTAnahtar Kelimeler: Karsinom; yassı epitel hücreli/patoloji;larengeal neoplaziler/patoloji; neoplasm metastazı; ciltneoplazileri/patoloji/ikincil.