Objectives: The effect of topical N-acetylcysteine
(NAC) application was investigated on the healing of
acute experimental tympanic membrane perforations.
Materials and Methods: Twenty guinea pigs were
used in this study. Under intraperitoneal ketamine
anesthesia, incisional myringotomies were performed
in the posterosuperior quadrant of the tympanic
membranes with a straight otologic hook.
The diameter of the perforations was approximately
2 mm. Perforations in both ears were treated with
freshly prepared sponges soaked in either 0.1 ml
0.9% NaCl solution (10 control animals) or 0.6
mg/0.1 ml NAC (10 animals) for three consecutive
days. All the tympanic membranes were examined
by otomicroscopy on the third, fifth, seventh, and
Results: In the control group, all the perforations
were completely closed at the end of nine days.
During the same period, only 40% of the perforations
were completely closed in the NAC group. The
remaining ears exhibited otorrhea by the third day.
Conclusion: N-acetylcysteine may cause severe
otorrhea in the healing process of tympanic membrane
perforations. Further studies including
histopathological examinations are required to elucidate
FREE FULL TEXTAnahtar Kelimeler: Asetilsistein; orta kulak/cerrahi; ortakulak ventilasyonu; timpanoplasti.