E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat Laryngeal inflammatory myofibroblastic tumor mimicking advanced stage malignancy [Tr-ENT]
Tr-ENT. 2020; 30(2): 66-70 | DOI: 10.5606/Tr-ENT.2020.51422

Laryngeal inflammatory myofibroblastic tumor mimicking advanced stage malignancy

Ayşegül Gönen1, Necati Enver2, İrem Sahver İşgör3, Leyla Cinel3, Çağatay Oysu2
1Department of Otorhinolaryngology Head and Neck Surgery, Kırklareli State Hospital, Kırklareli, Turkey
2Department of Otorhinolaryngology Head and Neck Surgery, Marmara University Medical Faculty Research and Training Hospital, Istanbul Turkey
3Department of Pathology, Marmara University Medical Faculty Research and Training Hospital, Istanbul Turkey

Inflammatory myofibroblastic tumors (IMTs), also known as inflammatory pseudotumors, plasma cell granulomas or inflammatory fibrosarcomas, are neoplastic lesions which primarily occur in children and are most frequently described in the lungs. They rarely affect the head and neck region. A 63-year-old female patient presented with an extremely large tumor which obstructed the airway. Total laryngectomy was performed. The diagnosis was atypical spindle cell proliferation and inflammatory cells without necrosis and an increased mitotic activity compatible with an IMT. The definitive diagnosis was achieved with positive cytoplasmic anaplastic lymphoma kinase-1 (ALK)-1 immunoreactivity. In conclusion, it is critical to evaluate patients carefully to distinguish IMT from mimicking diseases through endoscopic, radiological, histopathological, and immunohistochemical assessment to make tailor the treatment plan.

Keywords: Immunohistochemistry, inflammatory myofibroblastic tumor, larynx

Ayşegül Gönen, Necati Enver, İrem Sahver İşgör, Leyla Cinel, Çağatay Oysu. Laryngeal inflammatory myofibroblastic tumor mimicking advanced stage malignancy. Tr-ENT. 2020; 30(2): 66-70

Corresponding Author: Ayşegül Gönen, Türkiye
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