E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea? [Tr-ENT]
Tr-ENT. 2020; 30(2): 52-57 | DOI: 10.5606/Tr-ENT.2020.91885

Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?

Üstün Osma1, Ömer Tarık Selçuk1, Mete Eyigör2, Levent Renda1, Nursel Türkoğlu Selçuk3, Hülya Eyigör1, Mustafa Deniz Yılmaz1, Oguzhan İlden1, Ünal Gökalp Işık1, Hande Konsuk Unlu4, Meral Gultekin2
1Department of Otorhinolaryngology Head and Neck Surgery, Antalya Training and Research Hospital, Antalya, Turkey
2Department of Microbiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
3Department of Pulmonary Medicine and Sleep, Antalya Training and Research Hospital, Antalya, Turkey
4The Institute of Public Health, Hacettepe University, Ankara, Turkey

INTRODUCTION: The aim of this study was to evaluate serum copeptin levels in patients with obstructive sleep apnea (OSA) before and after the positive airway pressure (PAP) treatment.
METHODS: A total of 16 patients (14 males, 2 females; median age 48 years; range, 38 to 60 years) with severe sleep apnea based on the Apnea Hypopnea Index (AHI) >30 and 20 healthy controls (10 males, 10 females; median age 35.5 years; range, 22 to 47 years) were included in this study between October 2014 and December 2015. Full-night polysomnography was applied to each patient. Serum copeptin levels were determined using the enzyme-linked immunosorbent assay in both groups. Serum copeptin level measurement was repeated in the patient group after one year of PAP treatment.
RESULTS: After one year of PAP treatment, serum copeptin levels of the patients with OSA decreased, although there was no statistically significant difference before and after treatment.
DISCUSSION AND CONCLUSION: Increased serum copeptin concentration may reflect a response to moderate stress in many diseases, particularly cardiovascular diseases. Based on our study results, there was no significant difference between the severe OSA group and healthy volunteers and before and after treatment among the patients with severe OSA.

Keywords: Copeptin, severe obstructive sleep apnea, sleep apnea, vasopressin

Üstün Osma, Ömer Tarık Selçuk, Mete Eyigör, Levent Renda, Nursel Türkoğlu Selçuk, Hülya Eyigör, Mustafa Deniz Yılmaz, Oguzhan İlden, Ünal Gökalp Işık, Hande Konsuk Unlu, Meral Gultekin. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. 2020; 30(2): 52-57

Corresponding Author: Ünal Gökalp Işık, Türkiye
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