E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs [Tr-ENT]
Tr-ENT. 2005; 15(2): 70-77

Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs

Erdoğan Bulut1, Recep Yağız, Abdullah Taş, Cem Uzun, Çetin Yıldırım, Kadir Kaymak, Ahmet R. Karasalihoğlu

Objectives: This experimental study was performed to
evaluate the protective effect of magnesium on amikacin
ototoxicity.
Study Design: Twenty seven guinea pigs (54 ears)
with normal auropalpebral reflexes and otomicroscopic
examination, auditory brain stem responses (ABR),
and transient evoked otoacoustic emissions (TEOAE)
were randomly divided into four groups to receive
amikacin once 15 mg/kg daily (group 1 and 3) and
twice 7.5 mg/kg daily (group 2 and 4) for seven days.
Groups 3 and 4 were administered oral MgCl an hour
after amikacin use at a dose of 39 mmol/l and 19.5
mmol/l, respectively, for seven days. Otomicroscopic
examination, ABR and TEOAE measurements were
repeated on the third, fifth, and seventh days.
Results: Compared to group 1, decreases in TEOAE
amplitudes and reproducibility and increases in ABR
thresholds were significant in group 2 (p<0.05).
However, in groups 3 and 4, TEOAE amplitudes
remained unchanged, or even increased and the reproducibility
of TEOAE responses and ABR thresholds
showed no significant changes (p>0.05).
Conclusion: Our data show that oral magnesium may
play a protective role on amikacin ototoxicity.

Keywords: Amikacin/toxicity; auditory threshold/drug effects;cochlea/drug effects; evoked potentials, auditory, brain stem;guinea pigs; otoacoustic emissions, spontaneous; magnesium/therapeutic use.

Amikasin ototoksisitesinde magnezyumun koruyucu etkisinin kobaylarda elektrofizyolojik testlerle değerlendirilmesi

Erdoğan Bulut1, Recep Yağız, Abdullah Taş, Cem Uzun, Çetin Yıldırım, Kadir Kaymak, Ahmet R. Karasalihoğlu

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Anahtar Kelimeler: Amikasin/toksisite; işitme eşiği/ilaç etkisi;koklea/ilaç etkisi; uyarılmış potansiyeller, işitsel, beyinsapı;guinea pig; otoakustik emisyonlar, spontan; magnezyum/terapötk kullanım.

Erdoğan Bulut, Recep Yağız, Abdullah Taş, Cem Uzun, Çetin Yıldırım, Kadir Kaymak, Ahmet R. Karasalihoğlu. Evaluation of the protective effect of magnesium on amikacin ototoxicity by electrophysiologic tests in guinea pigs. Tr-ENT. 2005; 15(2): 70-77

Corresponding Author: Erdoğan Bulut
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